Antioxidants

Antioxidants inhibit TNF -induced motility and invasion of human osteosarcoma cells: Possible involvement of NFB activation

Potentiation of the Effect of Paclitaxel and Carboplatin by Antioxidant Mixture on Human Lung Cancer H520 Cell 

Vitamin D Analogues Suppress IGF-I Signalling and Promote Apoptosis in Breast Cancer Cells

a-Tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosis

Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery

Antitumor effect of nutrient synergy on human osteosarcoma cells U-2OS, MNNG-HOS and Ewing's sarcoma SK-ES.1

Biology

Biology of Childhood Osteogenic Sarcoma and Potential Targets for Therapeutic Development: Meeting Summary

Bisphosphonates

The third-generation bisphosphonates inhibit proliferation of murine osteosarcoma cells with induction of apoptosis

Elevated Physiologic Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma

Induction of cell death of human osteogenic sarcoma cells by zoledronic acid resembles anoikis

Anticancer Effects of Zoledronic Acid against Human Osteosarcoma Cells

Caffeine

Sensitization and Caffeine Potentiation of Cisplatin Cytoxicity Resulting from Introduction of Wild-Type p53 Gene in Human Osteosarcoma

Caffeine Inhibits Cell Proliferation by G0/G1 Phase Arrest in JB6 Cells

Chemokine

Messenger RNAExpression Levels of CXCR4 Correlatewith Metastatic Behavior and Outcome in Patients with Osteosarcoma

Chemotherapy Candidates

Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells

4-Demethoxy-30-deamino-30-aziridinyl-40-methylsulphonyldaunorubicin (PNU-159548): A promising new candidate for chemotherapeutic treatment of osteosarcoma patients

Gefitinib Enhances the Antitumor Activity and Oral Bioavailability of Irinotecan in Mice

Fluoxetine Inhibits Multidrug Resistance Extrusion Pumps and Enhances Responses to Chemotherapy in Syngeneic and in Human Xenograft Mouse Tumor Models

Novel effect of Y-24180, a presumed specific platelet-activating factor receptor antagonist, on Ca2+ levels and growth of human osteosarcoma cells

Chemotherapy Resistant

An Expression Signature Classifies Chemotherapy-Resistant Pediatric Osteosarcoma

Chemosensitivity

Elevated Physiologic Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma

Chemosensitivity of Osteosarcoma In Vitro and Multiple Drug Resistance Gene Expression

In Vitro Drug Testing in Osteosarcoma Cell Lines

Human Osteosarcoma Xenografts and Their Sensitivity to Chemotherapy

Cisplatin

Cisplatin (CDDP) speci®cally induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma

Delay in administration of CDDP until completion of AGM-1470 treatment enhances antimetastatic and antitumor effects

Sensitization and Caffeine Potentiation of Cisplatin Cytoxicity Resulting from Introduction of Wild-Type p53 Gene in Human Osteosarcoma

Influence of Cellular Factors and Pharmacokinetics on the Formation of Platinum-DNA Adducts in Leukocytes of Children Receiving Cisplatin Therapy

Hsp90 Inhibitors Deplete Key Anti-Apoptotic Proteins in Pediatric Solid Tumor Cells and Demonstrate Synergistic Anticancer Activity With Cisplatin

Doxorubicin

2-Deoxy-D-glucose Increases the Efficacy of Adriamycin and Paclitaxel in Human Osteosarcoma and Non-Small Cell Lung Cancers In Vivo

Analysis of Senesitivity to Doxorubicin in High Grade Osteosarcoma

Repopulation of osteosarcoma cells after treatment with doxorubicin in the presence of extracellular matrix biopolymers

ET-743

Effectiveness of Ecteinascidin-743 against Drug-sensitive and -resistant Bone Tumor Cells1

ERB-2

ErbB2 and bone sialoprotein as markers for metastatic osteosarcoma cells

Expression of HER2/erbB-2 Correlates With Survival in Osteosarcoma

Essential erbB Family Phosphorylation in Osteosarcoma as a Target for CI-1033 Inhibition

Ezrin

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

Gemcitabine

Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases

Heat Shock Protein

HSP90 Topotarget

Antibodies to heat shock protein 90 in osteosarcoma

patients correlate with response to neoadjuvant chemotherapy.

Expressional patterns of chaperones in ten human tumor cell lines

Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins

Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?

Heat Treatment

Role of Heat Treatment in Childhood Cancers: Distinct Resistance Profiles of Solid Tumor Cell Lines Towards Combined Thermochemotherapy

Immunotherapy

Effect Of Human Natural Killer and
 T Cells on the Growth of Human Autologous Melanoma Xenografts in SCID Mice

Nuclear Factor-
B is an Important Modulator of the Altered Gene Expression Profile and Malignant Phenotype in Squamous Cell Carcinoma

Effect of TNF-a on human osteosarcoma cell line Saos2dTNF-a regulation of bone sialoprotein gene expression in Saos2 osteoblast-like cells

Antitumor Activity of the Insulin-Like Growth Factor-I Receptor Kinase Inhibitor NVP-AEW541 in Musculoskeletal Tumors

OVEREXPRESSION OF IL-6 BUT NOT IL-8 INCREASES PACLITAXEL RESISTANCE OF U-2OS HUMAN OSTEOSARCOMA CELLS

Identification of Human Autologous Cytotoxic T-Lymphocyte-Defined Osteosarcoma Gene That Encodes a Transcriptional Regulator, Papillomavirus Binding Factor

The frequent expression of cancer/testis antigens provides opportunities for immunotherapeutic targeting of sarcoma

Phenotypic and functional analysis of lymphocytes infiltrating osteolytic tumors: use as a possible therapeutic approach of osteosarcoma  

Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFnB

Interferon

Interferon-a Enhances the Sensitivity of Human Osteosarcoma Cells to Etoposide

Interferon-gamma renders tumors that express low levels of Her-2/neu sensitive to cytotoxic T cells

Interferon-g Sensitizes Osteosarcoma Cells to Fas-Induced Apoptosis by Up-Regulating Fas Receptors and Caspase-8

Interleukin-12

Intranasal Interleukin-12 Gene Therapy Enhanced the Activity of Ifosfamide against Osteosarcoma Lung Metastases

Aerosol Gene Therapy with PEI:IL-12 Eradicates Osteosarcoma Lung Metastases

Magnetic Fields

Low-Voltage Electrochemotherapy with Low-Dose Methotrexate Enhances Survival in Mice with Osteosarcoma

Magnetic Field Induced Inhibition of Human Osteosarcoma Cells Treated With Adriamycin  

Drug Resistance Modifaction Using Pulsing Electromagnetic Field Stimulation for Multidrug Resistant Mouse Osteosarcoma Cell Line

MET Expression

Matrix Metalloproteinases Participate in Osteosarcoma Invasion

MET Overexpression Turns Human Primary Osteoblasts into Osteosarcomas

Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma

Metastasis Prevention

Absence of the CD44 Gene Prevents Sarcoma Metastasis

Metastasis-associated Differences in Gene Expression in a Murine Model of Osteosarcoma

Methotrexate

Mechanisms of Methotrexate Resistance in Osteosarcoma1

Low-dose methotrexate inhibits lung metastasis and lengthens survival in rat osteosarcoma

Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells

A Plasmin-derived Hexapeptide from the Carboxyl End of Osteocalcin Counteracts Oxytocin-mediated Growth of Inhibition of Osteosarcoma Cells

Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer

Essential role of RSK2 in c-Fos–dependent osteosarcoma development

Human polyomavirus BK (BKV) transiently transforms and persistently infects cultured osteosarcoma cells

Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells

Nonylphenol-induced Ca2+ elevation and Ca2+-independent cell death in human osteosarcoma cells

Osteogenic Protein-1 Stimulates Production of Insulin-Like Growth Factor Binding Protein-3 Nuclear Transcripts in Human Osteosarcoma Cells

Uric Acid Promotes Tumor Immune Rejection

Prognosis

Cytochrome P450 CYP3A4/5 Expression as a Biomarker of Outcome in Osteosarcoma

Human Epidermal Growth Factor Receptor 2 as a Prognostic Indicator in Osteogenic Sarcoma

Evaluation of P-Glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in Primary Tumor and Metachronous Lung Metastases in Patients with High-Grade Osteosarcoma

Stem Cell

Stem-Like Cells in Bone Sarcomas: Implications for Tumorigenesis

Survivin

Expression of Survivin and Correlation with PCNA in Osteosarcoma

Survivin expression in human osteosarcoma is a marker for survival

Telomerase

Telomerase Expression Predicts Unfavorable Outcome in Osteosarcoma

Telomerase-Independent Telomere Length Maintenance in the Absence of Alternative Lengthening of Telomeres–Associated Promyelocytic Leukemia Bodies

VEGF

Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells

C-Terminal Parathyroid Hormone-Related Protein Increases Vascular Endothelial Growth Factor in Human Osteoblastic Cells

Transforming growth factor-b1 modulates the expression of vascular endothelial growth factor by osteoblasts