Metastatic Osteosarcoma Treatment

 

Aerosol Thoracic Chemotherapy

Article describing the method of giving aerosolized chemotherapy to children with lung metastases

Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases pdf

 

Anti-Copper Compounds inhibit VEGF

Treatment of Metastatic Cancer with Tetrathiomolybdate, an Anticopper, Anti angiogenic     Agent: Phase I Study

TM for lowering copper and angiogenesis phase II trial

 

Ariad(AP23573) and Bone Sarcoma


A Phase II Study of AP23573 in patients with advanced sarcomas

 

Chemotherapy for Metastatic Osteosarcoma

1998 Feasibility of high-dose chemotherapy and autologous peripheral blood stem cell transplantation in children with  high grade osteosarcoma

2002 High-dose chemotherapy in the treatment of relapsed osteosarcoma: an Italian sarcoma group study pdf

April, 2005 Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the Children's Cancer Group (CCG) experience.

1997 Ifosfamide and Etoposide in Childhood Osteosarcoma:  A phase II study of the French Society of paediatric Oncology

 Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a pediatric oncology group trial pdf This trial had significant morbidity and mortality but had half the patients responding with some complete responses

High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity

Ifosfamide tolerance in osteosarcoma patients previously treated with cis-diamminedichloroplatinum-II: renal, hematologic, and neurologic observations

 

 

 

Chemokine


Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma

U.S. Patent for Chemokine's CXCR4 antagonists

 

Interferon-alpha

Interferon-induced depression and cognitive impairment in hepatitis C virus patients: a 72 week prospective study

 Interferon-alpha side effect profile

Interferon-alpha: regulatory effects on cell cycle and angiogenesis  

Interferon-alpha enhances the sensitivity of human osteosarcoma cells to etoposide pdf

ATRA and interferon-alpha in the treatment of a patient with resistant metastatic osteosarcoma

(full text) Effects of Interferon Alpha on Vascular Endothelial Growth Factor Gene Transcription and Tumor Angiogenesis

Interferon alpha 2a down-regulates VEGF expression through PI3 kinase and MAP kinase signaling pathways

Effectiveness of Type I interferons in the treatment of multidrug resistant osteosarcoma cells

 Long-term adjuvant interferon treatment of human osteosarcoma. A pilot study

  Interferon/Controlled study in 3-year survival of patients with osteosarcoma

 

Mental Side effects of Interferon-alpha Treatment


Prevention of interferon-alpha associated depression

Alpha-interferon and mental disorders
 Interferon alpha-induced depression in chronic hepatitis C patients: comparison between different types of interferon alpha

 

Interleukin-2 and osteosarcoma

Immunomodulation in a treatment program including pre- and post-operative interleukin-2 and chemotherapy for childhood osteosarcoma

Feasibility of high-dose interleukin-2 in heavily pretreated pediatric cancer patients

 

Inhibitors of serum VEGF

Serum vascular endothelial growth factor as a tumour marker in soft tissue sarcomas

Interferon-alpha: regulatory effects on cell cycle and angiogenesis  

Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound

Ellagic Acid        Rat study on Ellagic Acid


 

Innovative Lung Surgery

Laser-based cancer treatment for Lung Cancer

UPENN surgery for cancer-ridden lungs

American Cancer Ablation Center

New Procedure Destroys Lung Cancer In China Study

 

Prediction Assays for osteosarcoma patient pathology testing

Rational Therapeutics Treatment recommendations by assay-directed therapy

Genzyme Genetics Maker of DRA - Drug Resistance Assay Technology that assesses the resistance of tumor cells to specific drugs

 

Rapamycin-mTor inhibitors

protein kinase inhibitors : Rapamycin Chemical Analysis of Rapamycin

From Easter Island Soil to Treating Sarcoma—Rapamycin Derivatives

An expanding role for mTOR in cancer

Pharmacogenomic profiling of the PI3K/PTEN-AKT-mTOR pathway in common human tumors

The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma.

Rapamycin Inhibits Ezrin-Mediated Metastatic Behavior in a Murine Model of Osteosarcoma

Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein

Interferon-small gamma, Greek engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein David Sabatini

 

 

Samariam +/- Gemcitabine


Oct. 2005 Gemcitabine radiosensitization after high-dose samarium for osteoblastic osteosarcoma. pdf

Jan.2002 High-dose samarium-153 ethylene diamine tetramethylene phosphonate: low toxicity of skeletal irradiation in patients with bone metastases pdf

Mayo Clinic Mayo Clinic study finds radioactive drug samarium hopeful new treatment for osteosarcoma

Mayo Clinic High-dose samarium-153 ethylene diamine tetramethylene phosphonate: low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases. pdf

 

Vaccine and Osteosarcoma

Immune responses to the 105AD7 human anti-idiotypic vaccine after intensive chemotherapy, for osteosarcoma  vaccine for osteosarcoma

 

Valproic Acid

Mar. 2004 full-text Valproic acid inhibits angiogenesis in vitro and in vivo