2003 full text Osteogenic and Ewing Sarcomas: Estimation of Necrotic Fraction during Induction Chemotherapy with Dynamic Contrast-enhanced MR Imaging

May 1990 Thallium-201 scintigraphy in bone sarcoma: comparison with gallium-67 and technetium-MDP in the evaluation of chemotherapeutic response

Aug. 1993 Serial thallium-201 scintigraphy in osteosarcoma. Correlation with tumor necrosis after preoperative chemotherapy

Aug. 2004 Colour Doppler ultrasound predicts chemotherapy response, but not survival in paediatric osteosarcoma

2005 abstract PET/CT Evaluation
2005 full text PET/CT in the Evaluation of Childhood Sarcomas St. Jude Hospital

Arteriograms in Estimating effect of Neoadjuvant Chemotherapy to Osteosarcoma

  Angiography in Osteosarcoma

1982 abstract Radiographic and angiographic changes in osteosarcoma after intraarterial chemotherapy

1986 abstract The angiographic response of osteosarcoma following pre-operative chemotherapy

Mar. 1989 Osteosarcoma: angiographic assessment of response to preoperative chemotherapy

2005 abstract The Value of Serial Arteriography in Osteosarcoma
2005 full text The Value of Serial Arteriography in Osteosarcoma: Delivery of Chemotherapy, Determination of Therapy Duration, and Prediction of Necrosis Institute for Limb Preservation, Denver Colorado Dr. Wilkins
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Non-Metastatic Osteosarcoma
Nov. 1974 Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma. Pdf

Jul. 1977 High-dose methotrexate with citrovorum factor in osteogenic sarcoma--progress report II

Jun. 1979 Primary osteogenic sarcoma: the rationale for preoperative chemotherapy and delayed surgery

Jan. 1981 Systemic hypertension: complication of intra-arterial cis-diammine dichloroplatinum (II) infusion.

Apr. 1981 Osteogenic sarcoma: eight-percent, three-year, disease-free survival with combination chemotherapy (T-7)

Apr. 1981 High-dose methotrexate in osteogenic sarcoma

1981 High-dose methotrexate in osteogenic sarcoma adjuvant chemotherapy and limb salvage results

Feb. 1983 Osteosarcoma: intra-arterial treatment of the primary tumor with cis-diammine-dichloroplatinum II (CDP). Angiographic, pathologic, and pharmacologic studies

Apr. 1983 Osteogenic sarcoma: alterations in the pattern of pulmonary metastases with adjuvant chemotherapy

1985 Preoperative (neoadjuvant) chemotherapy for osteogenic sarcoma: a ten year experience

Aug. 1985 Control of primary osteosarcoma with chemotherapy

Jun. 1986 The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity

Aug. 1987 Weekly high-dose methotrexate and doxorubicin for osteosarcoma: the Dana-Farber Cancer Institute/the Children's Hospital--study III

Aug. 1986 pdf Weekly high-dose methotrexate and doxorubicin for osteosarcoma: the Dana-Farber Cancer Institute/the Children's (1987) Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial

1999 Hyperthermic isolated regional perfusion for the treatment of osteosarcoma in the lower extremity

Nov. 1999 Nonmetastatic osteosarcoma of the extremity: results of a neoadjuvant chemotherapy protocol (IOR/OS-3)with high-dose methotrexate, intraarterial or intravenous cisplatin, doxorubicin, and salvage chemotherapy based on         histologic tumor response

1999 Japan Marginal excision for osteosarcoma with caffeine assisted chemotherapy
Caffeine 1 Caffeine 2 Caffeine 3 Caffeine 4 Caffeine 5 Caffeine 6

Dec. 2000 Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report.

2001 Current treatment of Osteosarcoma
Sept. 2001 Definitive intraoperative very high-dose radiotherapy for localized osteosarcoma in the extremities

Oct. 2002 Dose-intense ifosfamide/doxorubicin/cisplatin based chemotherapy for osteosarcoma in adults

Feb. 2003 Review Progress and stagnation in chemotherapy protocols for primary osteosarcoma

May 2003 Immunomodulation in a treatment program including pre- and post-operative interleukin-2 and chemotherapy for childhood osteosarcoma

2003 abstract Superior survival in treatment of primary nonmetastatic pediatric osteosarcoma of the extremity

2003 full text Superior survival in treatment of primary nonmetastatic pediatric osteosarcoma of the extremity

Dec. 2003 Preoperative Therapy Versus Immediate Surgery in Nonmetastatic Osteosarcoma

Apr. 2004 High-dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma

Jul. 2004 Neoadjuvant chemotherapy for osteosarcoma

Dec. 2004 Twenty-year follow-up of osteosarcoma of the extremity treated with adjuvant chemotherapy

Mar. 2005 Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate
 

 Mar. 2005 full text Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate

March 2005 Hyperthermic isolated regional perfusion with CDDP for bone and soft-tissue sarcoma of the lower limb: pharmacokinetics, thermal dose, toxicity, and feasibility

Sept. 2005 Abstract of proceeding article (Sept. 2005) Improved Survival in Primary Nonmetastatic Pediatric Osteosarcoma of the Extremity Denver, CO

Denver Protocol(1990) || Arteriogram || Overall Survival in Denver || Cardio-toxicity || Audiogram testing

Metastatic Osteosarcoma at Diagnosis
Oct. 1985 Treatment of unresectable or metastatic osteosarcoma with cisplatin or cisplatin-doxorubicin

Mar. 1993 Osteogenic sarcoma with clinically detectable metastasis at initial presentation

(Nov. 1998) Treatment of metastatic osteosarcoma at diagnosis: a Pediatric Oncology Group Study

Mar. 2000 Neoadjuvant chemotherapy for osteosarcoma of the extremities with synchronous lung metastases: treatment with cisplatin, adriamycin and high dose of methotrexate and ifosfamide

2001 Presurgical window of carboplatin and surgery and multidrug chemotherapy for the treatment of newly diagnosed metastatic or unresectable osteosarcoma: Pediatric Oncology Group Trial

Jan. 2002 Phase II/III Trial of Etoposide and High-Dose Ifosfamide in Newly Diagnosed Metastatic Osteosarcoma: A Pediatric Oncology Group Trial pdf

April. 2002 CANCER MEDICINE: CASE DISCUSSIONS: Osteogenic Sarcoma Presenting with Lung Metastasis


Metastatic Osteosarcoma
Jun. 1973 Favorable response of metastatic osteogenic sarcoma to pulse high-dose methotrexate with citrovorum rescue and radiation therapy

Oct. 1976 Multidisciplinary treatment for macrometastatic osteogenic sarcoma

Oct. 1997 Phase II study of recombinant interleukin 1alpha and etoposide in patients with relapsed osteosarcoma

Apr. 1998 A Southwest Oncology Group and Cancer and Leukemia Group B phase II study of doxorubicin, dacarbazine, ifosfamide, and mesna in adults with advanced osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma

Jan. 2002 High-Dose Samarium-153 Ethylene Diamine Tetramethylene Phosphonate: Low Toxicity of Skeletal Irradiation in Patients With Osteosarcoma and Bone Metastases

Aug. 2003 Aerosol gene therapy with PEI: IL-12 eradicates osteosarcoma lung metastases

Mar. 2005 Immune responses to the 105AD7 human anti-idiotypic vaccine after intensive chemotherapy, for osteosarcoma

Mar. 2005 High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity

Sept. 2005 Aerosol gemcitabine inhibits the growth of primary osteosarcoma and osteosarcoma lung metastases

Adjuvant Interferon-alpha

Interferon-alpha as the only adjuvant treatment in high-grade osteosarcoma: Long term results of the Karolinska Hospital series

Methotrexate

Jul. 1994 Methotrexate pharmacokinetics and prognosis in osteosarcoma

March, 1999 Mechanisms of methotrexate resistance in osteosarcoma

2002 Bayesian estimation of methotrexate pharmacokinetic parameters and area under the curve in children and young adults with localized osteosarcoma

2004 High-dose methotrexate pharmacokinetics and outcome of children and young adults with osteosarcoma.

June, 2005 Methotrexate levels and outcome in osteosarcoma

Antioxidants and Concurrent Chemotherapy

Naturopathy and chemotherapy Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness

Cancer chemotherapy and antioxidants

Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects

Coenzyme q10 for prevention of anthracycline-induced cardiotoxicity.

Anthracycline-induced cardiotoxicity in children with cancer: strategies for prevention and management