Chemotherapy Results by Institution

Cooperative Osteosarcoma Studies Germany, Austria (Winkler)

1983  Toxicity associated with combination chemotherapy for osteosarcoma: a report of the cooperative osteosarcoma study (COSS 80).

1983 Adjuvant chemotherapy in osteosarcoma - effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin. Preliminary results of the COSS 80 study

1993 COSS results

Feb. 1998   Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response

Dana-Farber Cancer Institute/Children's Hospital Boston, Mass. (Jaffe, Goorin, Grier)

Nov. 1974 Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma. pdf

1981  High-dose methotrexate in osteogenic sarcoma

Aug. 1986  Weekly high-dose methotrexate and doxorubicin for osteosarcoma: the Dana-Farber Cancer Institute/the Children's pdf

(1987) Adjuvant chemotherapy for osteosarcoma: a randomized prospective trial

 

European Osteosarcoma Intergroup Study

  Received-dose and dose intensity of chemotherapy and outcome in nonmetastatic extremity Osteosarcoma

 

Institute for Limb Preservation Denver, Colorado (Wilkens)

Institute for Limb Preservation 2002 Results on Osteosarcoma

Improved Survival in Primary Nonmetastatic Pediatric Osteosarcoma of the Extremity   pdf 2003 pdf 2005

Denver Protocol(1990) || Arteriogram || Overall Survival in Denver || Cardio-toxicity || Audiogram testing

Institito Orthopedico Rizzoli Italy (Bacci)

Jun. 1990 Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for osteosarcoma of the extremities. The Istituto Rizzoli Experience in 127 patients treated preoperatively with intravenous methotrexate (high versus moderate doses) and intraarterial cisplatin

Dec. 2000 Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report.
 

IOR Osteosarcoma results

IORT Osteosarcoma results

Japan (Tschiyua)

1998 Caffeine-assisted chemotherapy and minimized tumor excision for nonmetastatic osteosarcoma

1999 Marginal excision for osteosarcoma with caffeine assisted chemotherapy

1999 Japan Marginal excision for osteosarcoma with caffeine assisted chemotherapy
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