Chemokines
Companies

         Chemokine Vancouver, CA CTCE-9908

  Biokine Israel BKT140 a cxcr4 antagonist

 

CTCE-9908 Inhibitor of CXCR4

Inhibition of metastases in preclinical models of osteosarcoma

The CXCR4 Antagonist CTCE-9908 Inhibits SDF-1-Induced Angiogenesis

ctce-9908  pipeline for ctce-9908
Chemokine Therapeutics Corp. Financials


Information on Chemokines

Pictures of chemokines

The chemokine network in cancer- much more than directing cell movement

A genetic approach to inactivating chemokine receptors using a modified viral protein pdf

Publications on chemokines from Chemokine Therapeutics


Feb. 2005 Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells

Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma  pdf

CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis pdf

Human osteosarcoma cells release matrix degrading enzymes in response to chemokine activation
 

Chemokine Involvement with Cancer

Small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors

Expression pattern of CXC chemokine receptor-4 is correlated with lymph node metastasis in human invasive ductal carcinoma pdf

Expression of CXC chemokine receptors 1-5 and their ligands in human glioma tissues: Role of CXCR4 and SDF1 in glioma cell proliferation and migration. pdf

Chemokine receptor cxcr4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome pdf

Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma  pdf

The Chemokine Receptor cxcr4 is regulated by dna methylation in pancreatic cancer pdf

 

Uses of cxcr4 antagonists

Chemokines and disease pdf

The significance of cancer cell expression of the chemokine receptor CXCR4 pdf

Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. pdf

Chemokines and their receptors as therapeutic targets: the role of the SDF-1/CXCR4 axis
pdf

The Chemokine Receptor CXCR4 Is Expressed on the Megakaryocytic Lineage From Progenitor to Platelets and Modulates Migration and Adhesion
pdf

CXCR4 Activation induces epidermal growth factor receptor transactivation