Alternative Therapies in Osteosarcoma and Cancer
Immune System Overview
1a.
LNHC Cancer Immunotherapy Overvie
1b.
Glossary of Immune System Terms
I.
Cancer and the Immune System
II.
Immune System Control of
Tumors
III. Current Methods of
Osteosarcoma Immunology (Oncology Reports 2006)
IV.
Mechanisms of Multimodal therapy for people with cancer
Daniel Rubin N.D.
V.
Chapter 5: Tumor Immunology and Immunotherapy
VI. The Cancer Stem Cell: Evidence for its
origin as an injured autoreactive stem cell
VII.
Molecular immunological approaches to biotherapy of human cancers--a review, hypothesis and implications.
pdf
Immune Testing Biomarker
Testing
Immunosciences Lab
Beverly Hills, CA
Immunosciences Lab
pdf
request form
Homeopathy
Results of Ramakrishnan Plussing on Cancer 1993-2001
Catherine Coulter
Dr. Ramakrishnan
Homeopaths in the US
Introduction to Homeopathy
Dr. Moskowitz
A Critical Review of Homeopathy
Immunology and Homeopathy 2005
A
Homeopathic Approach to Cancer (Coulter, Ramakrishnan)
Dr. Moskowitz
Treating Cancer with Homeopathy
Townsend Letter
A homeopathic approach to cancer
Pancreatic Enzymes
Catalytic Formula
Evaluation of pancreatic proteolytic enzyme treatment of adenocarcinoma of the pancreas, with nutrition and detoxification support
pdf
Proenzyme therapy of cancer
pdf
Pancreatic enzyme extract improves survival in murine pancreatic cancer
pdf
2001
Mixture of trypsin, chymotrypsin and papain reduces formation of metastases and extends survival time of C57Bl6 mice with syngeneic melanoma B16
pdf
The Kelley Nutritional-Metabolic Cancer Program
In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans.
The Gonzalez study of Cancer
NK-Cells
nk cells, metastasis
Expansion of NK cells
A)AHCC
AHCC
MSKCC herb page
AHCC
An in-office evaluation of AHCC
Dr. James Belanger ND
pdf
Improved prognosis of postoperative hepatocellular carcinoma
patients when treated with functional foods: a prospective cohort study
(AHCC)
ahcc htm
pdf
Combination therapy of
active hexose correlated compound plus UFT significantly reduces the metastasis of rat
mammary adenocarcinoma
B)
In Vitro Expansion
Natural Killer Cells Brings
Hope to Children and Adults with Leukemia
Jun. 2005
Expansion of natural killer cells with lytic activity against autologous
blasts from adult and pediatric acute lymphoid leukemia patients in complete
hematological remission
(full-text)
pdf
Expansion of natural killer cells for use in acute lymphoid leukemia
C) ACNO
The effects of a Chinese herb formula, anti-cancer number one
(ACNO), on NK cell activity and tumor metastasis in rats.
pdf
D)
Minor Bupleurum
A polysaccharide fraction of shosaiko-to
active in augmentation of natural killer activity by oral administration.
pdf
Augmentation of NK activity after oral administration of a traditional Chinese medicine, xiao-chai-hu-tang (shosaiko-to)
E
)
Vitamin C
Enhancement of natural killer cell activity and T and B cell function by buffered vitamin C in patients exposed to toxic chemicals: the role of protein kinase-C
pdf
F) Integrative Approach
Increased tumor necrosis factor alpha (TNF-alpha) and natural killer cell (NK) function using an integrative approach in late stage cancers
pdf
Astragalus
Astragalus
American Ginseng
Effects of Ginseng on Angiogenesis
pdf
Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium).
A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-gamma productions in murine spleen cells induced by Con-A
Antioxidants
Antioxidant Power Super Nutrition
Consumpsion of Green Tea causes rapid Antioxidant Power in Humans(pdf)
BioFlavonoids
Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. fruit
Rhus verniciflua stokes
pdf
Table 1 |
Table 2 |
Table 3
Table 4 |
Table 5 |
Table 6
Table 7 |
Table 8 |
Table 9
Avemar
Glycolysis of Cancer
a) 2005 Inhibition of Glycolysis in Cancer Cells: A Novel Strategy to Overcome Drug Resistance Associated with Mitochondrial Respiratory Defect and Hypoxia
pdf
b) 2005
Glycolytic enzymes can modulate cellular life span.
2002
A metabolic hypothesis of cell growth and death in pancreatic cancer
pdf
Wheat germ extract decreases glucose uptake and RNA
ribose formation but increases fatty acid synthesis in MIA pancreatic
adenocarcinoma cells
pdf
Fermented Wheat Germ Extract (Avemar) in
the Treatment of Cancer
pdf
2002 Clinical Results from Avemar
A medical nutriment has supportive value in the treatment of colorectal cancer.
pdf
2005
Immunologic and biochemical effects of the fermented wheat germ extract Avemar
pdf
1998
Effect of Avemar and Avemar + vitamin C on tumor growth and metastasis in experimental animals
pdf
1999
MSC, a new benzoquinone-containing natural product
with antimetastatic effect
pdf
Bromelain
CoEnzyme
10 (CoQ 10)
Biochemical Functions of COQ10
CoEnzyme Q10: New Applications for Cancer Therapy
Partial and Complete Regression of Breast Cancer in patients in relation to
Coenzyme Q10
Apparent partial remission of breast cancer in 'high risk' patients supplemented with coenzyme Q10
pdf
Cordyceps
Cordyceps
Curcumin
Super Curcumin
Curcumin has Anti-Cancer effects
|
More Information on Curcumin's anti-cancer effects
Anticancer Potential of Curcumin (Review)
2005
Curcumin: The story so far
Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages
2005
Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma
pdf
2004
Phase I Clinical Trial of Oral Curcumin
Biomarkers of Systemic Activity and Compliance
pdf
Cyclooxygenase-2 expression and oxidative DNA
adductsin murine intestinal adenomas: Modification by dietary curcumin and
implications for clinical trials
Feb. 200
3 Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and Ikappa Balpha kinase in human
multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis
pdf
2000
Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated
metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages
Inactivation of akt and NF-kappaB play important
roles during indole-3-carbinol-induced apoptosis in breast cancer cells
Curcumin inhibits ROS during chemotherapy
pdf
Curcumin (diferuloylmethane) induces apoptosis through
activation of caspase-8, BID cleavage and cytochrome c release: its suppression
by ectopic expression of Bcl-2 and Bcl-xl.
pdf
Inhibitors of serum VEGF (Angiogenesis)
CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis
pdf
Messenger RNA Expression Levels of CXCR4 Correlate with
Metastatic Behavior and Outcome in Patients
with Osteosarcoma
A) Ellagic Acid
Combined inhibition of PDGF and VEGF
receptors by ellagic acid, a dietary-derived phenolic compound
Ellagic Acid
Rat study on Ellagic Acid
Synergistic Effect of low levels of Quercetin on ellagic acid
B) D-Limonene
Phase I/II Clinical Trials Committee
D-Limonene
Memorial Sloan-Kettering
Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign
pdf
2002 Japan
Mammary carcinomas induced in human c-Ha-ras
proto-oncogene transgenic rats are estrogen-independent, but responsive to d-limonene treatment
2004 China
Inhibition of growth and metastasis of
human gastric cancer implanted in nude mice by d-limonene.
full-text
pdf
C) Copper Chelation
Treatment of Metastatic Cancer with Tetrathiomolybdate, an Anticopper,
Antiangiogenic Agent: Phase I Study
pdf
Phase II Trial of Tetrathiomolybdate in Patients with Advanced Kidney Cancer
pdf
Essential Fatty Acids
Eicosapentaenoic acid inhibits the growth of liver preneoplastic lesions and alters membrane phospholipid composition and peroxisomal beta-oxidation
Effect of omega-3 fatty acids on the progression of metastases after the surgical excision of human breast cancer cell solid tumors growing in nude mice
Apparent partial remission of breast cancer in 'high risk' patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10
Flaxseed and its components reduce metastasis after surgical
excision of solid human breast tumor in nude mice
Genistein
Effect of genistein on the proliferation, differentiation and apoptosis of the
osteoblasts
The effects of genistein on the synthesis and
distribution of glycosaminoglycans/proteoglycans by two osteosarcoma cell
lines depends on tyrosine kinase and the estrogen receptor density.
Glycolysis of Cancer
2005 Inhibition of Glycolysis in Cancer Cells: A Novel Strategy to Overcome Drug Resistance Associated with Mitochondrial Respiratory Defect and Hypoxia
pdf
2005
Glycolytic enzymes can modulate cellular life span.
Graviola
Paw Paw
The Annonaceous acetogenin bullatacin is cytotoxic against
multidrug-resistant human mammary adenocarcinoma cells.
Green Tea
2003
Green tea polyphenol targets the mitochondria in tumor cells
inducing caspase 3-dependent apoptosis
Consumpsion of Green Tea causes rapid Antioxidant Power in Humans
Green tea polyphenol causes differential oxidative environments
in tumor versus normal epithelial cells.
Insulin Potentiation Therapy
1981
Metabolic modification by insulin enhances
methotrexate cytotoxicity in MCF-7 human breast cancer cells
1986
Insulin potentiation therapy: a new concept in the management of chronic degenerative disease.
pdf
1990
Insulin Potentiation Treatment of Breast Cancer
Indole-3-Carbinol(Brocolli extract)
Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
pdf
Ketogenic
Diet
LNHC Ketogenic Diet
Targeting energy metabolism in brain cancer: review and hypothesis
pdf
Role of glucose and ketone bodies in the metabolic control of experimental brain cancer
pdf
Implementing a ketogenic diet based on medium-chain triglyceride oil in pediatric patients with cancer
Effects of a ketogenic diet on tumor metabolism and nutritional status in
pediatric oncology patients: two case reports
pdf
Laktoferrin
Laktoferrin
Allergy Research Group
The therapeutic potential of lactoferrin
Lycopene
Lycopene II--effect on osteoblasts: the carotenoid lycopene
stimulates cell proliferation and alkaline phosphatase activity of SaOS-2
cells.
Melatonin
picture of melatonin
Dec. 1998
Melatonin In Osteosarcoma
pdf
Jul. 1997
Melatonin enhances IL-2, IL-6, and IFN-gamma production by
human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocyte
Dec. 1998
Involvement of nuclear binding sites for
melatonin in the regulation of IL-2 and IL-6 production by human blood
mononuclear cells
1997
Melatonin as a new possible
anti-inflammatory agent
2003
Melatonin counteracts the inhibitory effect of
PGE2 on IL-2 production in human lymphocytes via its mt1 membrane receptor
pdf
Multivitamin
Life Extension Capsules w/o copper
Panax Ginseng
Panax Ginseng
Pure Encapsulations
March 2003
Reversal of P-glycoprotein-mediated multidrug resistance by protopanaxatriol ginsenosides from Korean red ginseng
March 2003
Panax Ginseng: a role in cancer therapy?
Sept. 2003
Immune system effects of echinacea, ginseng, and astragalus: a review
2004
Cancer prevention and therapeutics: Panax ginseng
Immunostimulating effects of acidic polysaccharides extract of Panax ginseng on macrophage function.
2005
Evaluation of chemo preventive action and antimutagenic effect of the standardized Panax ginseng extract, EFLA400, in Swiss albino mice
Papaya Extract
Probiotics
Probiotics and Colon Cancer
Yogurt and Gut Function
PSK
Efficacy of adjuvant Immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials.
Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer.
pdf
Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer
pdf
Effect of krestin (PSK) as adjuvant treatment on the prognosis
after radical radiotherapy in patients with non-small cell lung cancer
Coriolus versicolor Supplementation Study as Adjunct Nutrition in 30 Solid
Tumor Cancer Patients
Gene expression in response to anti-tumor intervention by
polysaccharide-K (PSK) in colorectal carcinoma cells
Anticancer effects and mechanisms of polysaccharide-K (PSK):
implications of cancer immunotherapy
A review of research on the protein-bound polysaccharide
(polysaccharopeptide, PSP) from the mushroom Coriolus versicolor
(Basidiomycetes: Polyporaceae)
Effect of Krestin as adjuvant treatment following radical
radiotherapy in non-small cell lung cancer patients.
Red
Clover
Red Clover Extract
Solgar
Red clover extracts stimulate differentiation of human osteoblastic osteosarcoma HOS58 cells.
pdf
RU-486
The Glucocorticoid RU-486 and Cancer
Selenium(Se-methylselenocysteine)
Prediagnostic serum selenium and risk of cancer
Osteosarcoma cell apoptosis induced by selenium
Selenium and Cancer
Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells.
Sterols
Moducare
Siberian Ginseng (Eleuthro)
Siberian Ginseng
Nature's Way
Thalidomide
Thalidomide rxlist.com
Case of Controlled Remission with COX2-inhibitor and
thalidomide
2004
Review: Thalidomide
2005
Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells
2005
Suppression of urokinase expression and invasion by a soybean Kunitz trypsin inhibitor are mediated
through inhibition of Src-dependent signaling pathways
2005
Results of a phase 1 clinical trial of thalidomide in
combination with fludarabine as initial therapy for patients
with treatment-requiring chronic lymphocytic leukemia (CLL).
Ukrain (
Chelidonium majus L. alkaloid - thiophosphoric acid
derivative)
Celandine
Wise Woman Herbals
Ordering Ukrain
|
D
irections on
Using Ukrain |
Information for Physisians on Using Ukrai
n
A Brief Introduction to Ukrain
Introduction to Ukrain for Patients
Introduction to Ukrain for Physicians
Technical Intro to
Ukrain for Physicians
Abstracts on Ukrain
1998
Aschoff 1998
2000
Aschoff 2000
1998
Antitumor Activity of Ukrain and Macrophage Stimulation
2002 NSC-631570 (Ukrain) in the palliative treatment of pancreatic cancer. Results of a phase II trial.
Efficacy of Ukrain in the Treatment of Pancreatic Cancer
Ukrain-a new cancer cure. A systematic Review of randomized clinical trials
Valproic Acid (Histone Deacetylase
Inhibitors)
2005
Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent
expression of MHC class I-related chain A and B
pdf
2006
Epigenetics Therapy of Cancer(Review)
2006
Histone Deacytalase Inhibitors and the Promise of
epigenetic treatments of cancer
2004
Mechanism of histone deacetylase inhibitor Trichostatin A induced apoptosis in human osteosarcoma cells.
pdf
Valproic Acid Defines a Novel Class of HDAC Inhibitors
inducing differentiation in transformed cells
1999 Germany
Valproic acid for the treatment of pediatric malignant glioma.
Mar. 2004
full-text
Valproic acid inhibits angiogenesis in vitro and in vivo
pdf
May 2005
Valproic Acid Alters Chromatin Structure by Regulation of Chromatin Modulation Proteins
pdf
Aug. 2002
Valproate and valproate-analogues: potent tools to fight against cancer
Jul.
2004
Valproic acid inhibits proliferation and
induces apoptosis in acute myeloid leukemia cells expressing P- gand MRP1
Mar. 2005
Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine,
restores expression of silenced RARbeta2 in breast cancer cells
2005
Phase I Trial
The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia
pdf
Vanadium
Vanaphage Nutreuceutical Research Lab
Vanadium--an element of atypical biological significance
pdf
Vanadium in cancer treatment
pdf
Antitumoral properties of two new vanadyl(IV) complexes in
osteoblasts in culture: role of apoptosis and oxidative stress
pdf
A
possible role of oxidative stress in the vanadium-induced cytotoxicity in the MC3T3E1 osteoblast and UMR106 osteosarcoma cell lines
pdf
Vanadate Induces p53 Transactivation through Hydrogen Peroxide and Causes
Apoptosis
pdf
A vanadium/aspirin complex controlled release using a
poly(beta-propiolactone) film. Effects on osteosarcoma cells.
pdf
Vanadium derivatives act as growth factor--mimetic compounds
upon differentiation and proliferation of osteoblast-like UMR106 cells
Vascustatin
Vascustatin
Allergy Research Group
Vitamin C
Enhancement of natural killer cell activity and T and B cell function by buffered vitamin C in patients exposed to toxic chemicals: the role of protein kinase-C
pdf
1997
Enhancement of Human Natural Killer Cytotoxic Activity
by Vitamin C in Pure and Augmented formulations
Vojdani, Namatalla
2000
New evidence for antioxidant properties
of vitamin C
pdf
Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use
Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection
against oxidative injury
Effects of ascorbic acid on alkaline phosphatase activity and
hormone responsiveness in the osteoblastic osteosarcoma cell line UMR-106
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Vitamin D3
Oral Administration of 1 Alpha Hydroxyvitamin D3
Inhibits Tumor Growth and Metastasis of a Murine Osteosarcoma Model
Warburg
On the origin of cancer cells
Otto Warburg
Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.
pdf
Energy boost: the Warburg effect returns in a new theory of cancer
Breast Cancer Proves the Warburg Hypothesis
Yi Yi Ren (Kanglaite)
Kanglaite Fluid for sale
Phase I study of Kanglaite (KLT) a botanical product based on traditional Chinese medicine.
Globalizing Chinese Medicine
Zoledronic Acid
Zometa Side Effect Profile
Zoledronic
Acid(Zometa) suppresses lung metastases and prolongs overall survival of osteosarcoma-bearing
mice
Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma.
Bisphosphonates: new therapeutic agents for the treatment of bone tumors
___________________________________________________________________________
_____
Negative Results
Vitamin B17-Laetrile
A Clinical Trial of Laetrile in the treatment of
human cancer
Iron
The role of iron in cancer
Vitamin B1-Thiamine
Thiamine Supplementation to Cancer Patients: A Double-Edged Sword
Shark Cartilage
Phase I/II trial of the safety and efficacy of shark Cartilage in the treatment of advanced cancer
______________________________________________________________________________________
Information on
psoralea
Psoralea
and Prevention
of Metastasis of Osteosarcoma
Asimitrin and 4-hydroxytrilobin, new bioactive annonaceous
acetogenins from the seeds of Asimina triloba possessing a bis-tetrahydrofuran
ring
Psoralea Corylifolia (Bu gu zhi)
Psoralea is
one of the main herbs in traditional Chinese and Japanese herbal medicine for
the treatment of skin conditions. It has been used in the treatment of eczema
and hair loss. In addition, it acts against staph infections and helps stimulate
the heart. The Chinese name of this herb, bu gu zhi, means "tonify bone resin."
Psoralea is used to promote bone calcification, making it useful for treating
osteoporosis and bone fractures. Psoralens, components in psoralea, are active
principles for inducing pigmentation of the skin. They cause residual
pigmentation when applied on hypo-pigmented skin, together with increased blood
flow and melanin-producing activity in the affected area. Benefits of psoralea
for specific health conditions include the following: Cancer.
Psoralea contains
bavachinin, corylfolinin, and psoralen, all of which inhibit the multiplication
of osteosarcoma and lung cancer cells.
Psoriasis. Psoralea is a natural source
of psoralens, a group of chemicals that includes the active ingredient of a
conventional psoriasis medication called methoxsalen (8-MOP, Oxsoralen-Ultra).
Psoralens make ultraviolet-light therapy for this disorder more effective.
Vitiligo. Psoralea helps fight vitiligo, a disorder in which patches of skin
lose their pigmentation. In one study, forty-nine patients underwent six months
of psoralea treatment. Of these patients, 14 percent were cured and another 19
percent regained pigmentation on at least two-thirds of the affected skin.
Clinical response, vascular change, and angiogenesis in
gonadotropin-releasing hormone analogue-treated women with uterine myomas
Expert Opinion on Pharmacotherapy
Induction of apoptosis in human osteosarcoma Saos-2 cells by
the proteasome inhibitor MG132 and the protective effect of pRb.
Clinical observation on effect of chemotherapy combined with Chinese medicine in
treating advanced tumor patients and on immunologic parameters
Information on U-FN(Japanese Seaweed)
Information on Carnivora
New anticancer agents: in vitro and in vivo evaluation of the
antitumor and antimetastatic actions of various compounds isolated from
medicinal plant
SA and Immune System pdf
